Chambers is best known for his work for Games Workshop, where he worked from March 1990 to March 2004. He worked extensively on various Warhammer 40,000 rulebooks and sourcebooks, and also authored multiple fiction novels set in the same universe. Chambers was the lead designer on a number of Warhammer 40,000 spin-off games, such as Necromunda (1995) and Battlefleet Gothic (1999), produced by Specialist Games. These games were released at a time of major growth for Games Workshop and were designed with expansions and more miniatures sales in mind.
In 2003, Chambers joined Mongoose Publishing as the lead designer of the company’s development team for the Starship Troopers tabletop miniatures game. Starship Troopers won “Best New Game” in the 2005 Origins Awards.
Chambers was also made the lead story writer for Blizzard Entertainment’s StarCraft II: Wings of Liberty for which he is given much of the credit for completing the project by other members of the company such as Megan Farokhmanesh.
Andy Chambers has also been involved in numerous other projects over the years such as Dust Warfare (2012) releases by Fantasy Flight Games, Dropfleet Commander (2017) by Hawk Wargames and Blood Red Skies (2017) publisher by Warlord Games.
Like Jervis Johnson and Alessio Cavatore, Andy Chambers has been involved in the designing of over 100 rules and accompanying supplements for many publishers including Games Workshop, Warlord Games, Hawk Wargames and Fantasy Flight Games to name but a few.